MRT-81
CAS No. 1263132-08-6
MRT-81 ( —— )
Catalog No. M28744 CAS No. 1263132-08-6
MRT-81 inhibits human and rodent smoothened?Smo?receptors effectively with an IC50?value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 114 | Get Quote |
|
5MG | 192 | Get Quote |
|
10MG | 309 | Get Quote |
|
25MG | 525 | Get Quote |
|
50MG | 750 | Get Quote |
|
100MG | 1035 | Get Quote |
|
500MG | 2061 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMRT-81
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NoteResearch use only, not for human use.
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Brief DescriptionMRT-81 inhibits human and rodent smoothened?Smo?receptors effectively with an IC50?value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cancer.
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DescriptionMRT-81 inhibits human and rodent smoothened?Smo?receptors effectively with an IC50?value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cancer.(In Vitro):MRT-81 inhibits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatase positive osteoblasts induced by the Smo agonist SAG with 0.1 μM, with an IC50?value of 64 nM.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorhDHODH
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Research Area——
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Indication——
Chemical Information
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CAS Number1263132-08-6
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Formula Weight555.7
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Molecular FormulaC31H29N3O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESCOc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1ccc(C)c(NC(=O)c2ccc(cc2)-c2ccccc2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Munier-Lehmann H, et al. Original?2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine?derivatives?as?inhibitors?of?human?dihydroorotate?dehydrogenase?(DHODH). J Med Chem.?2015 Jan 22;58(2):860-77.
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