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MRT-81

CAS No. 1263132-08-6

MRT-81 ( —— )

Catalog No. M28744 CAS No. 1263132-08-6

MRT-81 inhibits human and rodent smoothened?Smo?receptors effectively with an IC50?value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MRT-81
  • Note
    Research use only, not for human use.
  • Brief Description
    MRT-81 inhibits human and rodent smoothened?Smo?receptors effectively with an IC50?value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cancer.
  • Description
    MRT-81 inhibits human and rodent smoothened?Smo?receptors effectively with an IC50?value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cancer.(In Vitro):MRT-81 inhibits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatase positive osteoblasts induced by the Smo agonist SAG with 0.1 μM, with an IC50?value of 64 nM.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    hDHODH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1263132-08-6
  • Formula Weight
    555.7
  • Molecular Formula
    C31H29N3O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1ccc(C)c(NC(=O)c2ccc(cc2)-c2ccccc2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Munier-Lehmann H, et al. Original?2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine?derivatives?as?inhibitors?of?human?dihydroorotate?dehydrogenase?(DHODH). J Med Chem.?2015 Jan 22;58(2):860-77.
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