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MPTP-Hydrochloride
CAS No. 23007-85-4
MPTP-Hydrochloride( 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | NSC 139654 )
Catalog No. M13642 CAS No. 23007-85-4
MPTP (hydrochloride) is a prodrug to the neurotoxin MPP which causes permanent symptoms of Parkinson's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 27 | In Stock |
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| 10MG | 43 | In Stock |
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| 25MG | 80 | In Stock |
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| 50MG | 133 | In Stock |
|
| 100MG | 186 | In Stock |
|
| 200MG | 296 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMPTP-Hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionMPTP (hydrochloride) is a prodrug to the neurotoxin MPP which causes permanent symptoms of Parkinson's disease.
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DescriptionMPTP (hydrochloride) is a prodrug to the neurotoxin MPP which causes permanent symptoms of Parkinson's disease.(In Vitro):Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm.(In Vivo):The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.
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In Vitro——
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In Vivo——
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Synonyms1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | NSC 139654
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDopamine
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number23007-85-4
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Formula Weight209.72
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Molecular FormulaC12H16ClN
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Purity>98% (HPLC)
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SolubilityDMSO: 12 mg/mL
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SMILESCN1CCC(=CC1)C2=CC=CC=C2.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question). Life Sci., 1985, 36, No. 3, 201-12.
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