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MN-64

CAS No. 92831-11-3

MN-64( MN-64 | MN 64 | MN64 )

Catalog No. M17668 CAS No. 92831-11-3

MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 58 In Stock
25MG 115 In Stock
50MG 192 In Stock
100MG 312 In Stock
500MG 743 In Stock
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Biological Information

  • Product Name
    MN-64
  • Note
    Research use only, not for human use.
  • Brief Description
    MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
  • Description
    MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system. Tankyrases are ADP-ribosyltransferases that play key roles in various cellular pathways, including the regulation of cell proliferation, and thus, they are promising drug targets for the treatment of cancer.
  • In Vitro
    MN-64 is a potent tankyrase 1 inhibitor, with IC50s of 6 nM, 72 nM, 19.1 μM, 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively. MN-64 effectively inhibits Wnt/β-catenin at 1 μM, and blocks STF luciferase activity at 200 nM.
  • In Vivo
    ——
  • Synonyms
    MN-64 | MN 64 | MN64
  • Pathway
    Neuroscience
  • Target
    Gamma-secretase
  • Recptor
    Tankyrase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    92831-11-3
  • Formula Weight
    264.32
  • Molecular Formula
    C18H16O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL. 378.33 mM;
  • SMILES
    CC(C)c1ccc(cc1)c1cc(=O)c2ccccc2o1
  • Chemical Name
    2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Narwal M, et al. J Med Chem. 2013 Oct 24;56(20):7880-9.
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