Cart
sales@molnova.com
MMV390048
CAS No. 1314883-11-8
MMV390048( MMV 048 | MMV 390048 )
Catalog No. M11269 CAS No. 1314883-11-8
MMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 73 | In Stock |
|
| 5MG | 120 | In Stock |
|
| 10MG | 203 | In Stock |
|
| 25MG | 410 | In Stock |
|
| 50MG | 609 | In Stock |
|
| 100MG | 867 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMMV390048
-
NoteResearch use only, not for human use.
-
Brief DescriptionMMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain).
-
DescriptionMMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain); blocks all life cycle stages of the malaria parasite, exhibits full chemoprotection, delays relapse in a Plasmodium cynomolgi monkey model.Parasite Infection Phase 2 Clinical
-
In VitroMMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.
-
In Vivo——
-
SynonymsMMV 048 | MMV 390048
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI4K
-
RecptorPI4K
-
Research AreaInfection
-
IndicationParasite Infection
Chemical Information
-
CAS Number1314883-11-8
-
Formula Weight393.3842
-
Molecular FormulaC18H14F3N3O2S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (254.21 mM)
-
SMILESNC1=NC=C(C2=CC=C(S(C)(=O)=O)C=C2)C=C1C3=CN=C(C(F)(F)F)C=C3
-
Chemical Name5-(4-(methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Paquet T, et al. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.
molnova catalog
related products
-
UCB9608
UCB9608 (UCB-9608) is a potent, selective, orally bioavailable PI4KIIIβ inhibitor with IC50 of 11 nM.
-
UCT943
UCT943 (UCT-943) is a potent, selective, next generation Plasmodium falciparum PI4K inhibitor with IC50 of 23 nM.
-
PIK-93
PIK-93 is a potent, synthetic PI4K inhibitor with IC50 of 19 nM (PI4KIIIβ).
