Cart
sales@molnova.com
MMPSI
CAS No. 220509-74-0
MMPSI( —— )
Catalog No. M33769 CAS No. 220509-74-0
MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a concentration-dependent manner.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 149 | Get Quote |
|
| 5MG | 312 | Get Quote |
|
| 10MG | 502 | Get Quote |
|
| 25MG | 907 | Get Quote |
|
| 50MG | 1435 | Get Quote |
|
| 100MG | 2178 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMMPSI
-
NoteResearch use only, not for human use.
-
Brief DescriptionMMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a concentration-dependent manner.
-
DescriptionMMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetCaspase
-
RecptorCaspase | Apoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number220509-74-0
-
Formula Weight324.35
-
Molecular FormulaC14H16N2O5S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (308.31 mM; Ultrasonic )
-
SMILESO=C1C=2C(=CC=C(S(=O)(=O)N3[C@H](COC)CCC3)C2)NC1=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chapman JG, et al, Tracey WR. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol. 2002;456(1-3):59-68.?
molnova catalog
related products
-
Boc-Asp(OMe)-fluorom...
Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.
-
WF-210
WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM.
-
PAC1
PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.
