MMAD

CAS No. 203849-91-6

MMAD ( MMAD, Demethyldolastatin 10; Monomethyl Dolastatin 10 )

Catalog No. M18216 CAS No. 203849-91-6

MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 59 In Stock
10MG 104 In Stock
50MG 337 In Stock
100MG Get Quote In Stock
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Biological Information

  • Product Name
    MMAD
  • Note
    Research use only, not for human use.
  • Brief Description
    MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
  • Description
    MMAD, also known as Monomethyl auristatin D, is a highly potent tubulin inhibitor. MMAD is one of the auristatins, which are used as antibody drug conjugates (ADCs).
  • Synonyms
    MMAD, Demethyldolastatin 10; Monomethyl Dolastatin 10
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    Microtubule/Tubulin
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    203849-91-6
  • Formula Weight
    771.06
  • Molecular Formula
    C41H66N6O6S
  • Purity
    98%
  • Solubility
    DMSO : 24.5 mg/mL 31.77 mM;
  • SMILES
    O=C(N[C@@H](Cc1ccccc1)c2nccs2)[C@H](C)[C@@H](OC)[C@@H]3CCCN3C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C
  • Chemical Name
    (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.
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