Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Dopamine Receptor - MLS1547

MLS1547

CAS No. 315698-36-3

MLS1547( MLS-1547 | MLS 1547 | MLS000051547 )

Catalog No. M27901 CAS No. 315698-36-3

MLS1547 is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 39 Get Quote
10MG 53 Get Quote
25MG 79 Get Quote
50MG 111 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    MLS1547
  • Note
    Research use only, not for human use.
  • Brief Description
    MLS1547 is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.
  • Description
    MLS1547 is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.(In Vitro):MLS1547 fully antagonizes dopamine-mediated β-arrestin recruitment to the D2 dopamine receptor with an IC50 of 9.9 μM in the DiscoveRx assay and 3.8 μM in the BRET assay. MLS1547 is found to completely displace [3H]methylspiperone binding to the D2 dopamine receptor, with a calculated Ki of 1.2 μM.
  • In Vitro
    MLS1547 fully antagonizes dopamine-mediated β-arrestin recruitment to the D2R in the DiscoveRx assay, with an IC50 of 9.9 μM. Similar results were obtained when MLS1547 was examined for antagonist activity in the D2R β-arrestin BRET assay, demonstrating an IC50 of 3.8 μM. MLS1547 is found to completely displace [3H]methylspiperone binding to the D2R, with a calculated Ki of 1.2 μM.
  • In Vivo
    ——
  • Synonyms
    MLS-1547 | MLS 1547 | MLS000051547
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    SOD1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    315698-36-3
  • Formula Weight
    354.84
  • Molecular Formula
    C19H19ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (93.93 mM)
  • SMILES
    Oc1c(CN2CCN(CC2)c2ccccn2)cc(Cl)c2cccnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chisholm CL, et al. Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin. Oncotarget. 2016 Oct 31.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • FAUC-365

    FAUC-365 is a D3 dopamine receptor agonist.

  • Trifluoperazine dihy...

    An antiadrenergic, antidopaminergic and anticholinergic agent.

  • Bromocriptine mesyla...

    Bromocriptine (CB-154) is a dopamine D2 receptor agonist (Ki=3 nM) and and various serotonin receptors, also inhibits the release of glutamate by reversing the glutamate GLT1 transporter.

Sign In Join Free