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Home - Products - Metabolic Enzyme/Protease - Phosphatase - MLS000544460

MLS000544460

CAS No. 352336-36-8

MLS000544460( —— )

Catalog No. M33030 CAS No. 352336-36-8

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd: 2.0 μM, IC50: 4 μM) that exhibits inhibitory effects on Eya2 phosphatase-mediated cell migration and has anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 123 Get Quote
5MG 187 Get Quote
10MG 297 Get Quote
25MG 495 Get Quote
50MG 685 Get Quote
100MG 963 Get Quote
500MG 1935 Get Quote
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Biological Information

  • Product Name
    MLS000544460
  • Note
    Research use only, not for human use.
  • Brief Description
    MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd: 2.0 μM, IC50: 4 μM) that exhibits inhibitory effects on Eya2 phosphatase-mediated cell migration and has anticancer activity.
  • Description
    MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity.
  • In Vitro
    MLS000544460 does not bind Eya3 phosphatase (ED). MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg2+, it binds MLS000544460 with a higher affinity (Kd=0.80 μM), indicating that this class of compounds does not require Mg2+ for its interaction with the Eya2 ED.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    Phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    352336-36-8
  • Formula Weight
    341.36
  • Molecular Formula
    C17H12FN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (366.18 mM; Ultrasonic )
  • SMILES
    Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Krueger AB, et al. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cellmigration. J Biol Chem. 2014 Jun 6;289(23):16349-61.?
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