MLE-4901
CAS No. 941690-55-7
MLE-4901 ( MLE4901;AZD-2624;AZD2624;Pavinetant )
Catalog No. M16736 CAS No. 941690-55-7
A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMLE-4901
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.
-
DescriptionA potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia; demonstrates drug-like properties with low metabolic turnover rate in vitro and moderate human plasma protein binding.Schizophrenia Phase 2 Discontinued
-
SynonymsMLE4901;AZD-2624;AZD2624;Pavinetant
-
PathwayGPCR/G Protein
-
TargetNeurokinin Receptor
-
RecptorNeurokinin Receptor
-
Research AreaNeurological Disease
-
IndicationSchizophrenia
Chemical Information
-
CAS Number941690-55-7
-
Formula Weight459.56
-
Molecular FormulaC26H25N3O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 50 mg/mL 108.80 mM; H2O : < 0.1 mg/mL
-
SMILESO=C(C1=C(NS(=O)(C)=O)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@H](C4=CC=CC=C4)CC
-
Chemical Name(S)-3-(methylsulfonamido)-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Li Y, et al. Xenobiotica. 2010 Nov;40(11):721-9.
2. Skorupskaite K, et al. Neuroendocrinology. 2017 Apr 5. doi: 10.1159/000473893.
3. Prague JK, et al. Lancet. 2017 May 6;389(10081):1809-1820.
2. Skorupskaite K, et al. Neuroendocrinology. 2017 Apr 5. doi: 10.1159/000473893.
3. Prague JK, et al. Lancet. 2017 May 6;389(10081):1809-1820.
molnova catalog
related products
-
Talnetant
Talnetant is a selective competitive brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission.
-
R 396
R 396 is a linear hexapeptide and is also an NK-2 tachykinin receptor antagonist.
-
Hemokinin 1 (human)
Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.