ML365

Research use only, not for human use.

ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).

ML365 is a potent and selective K2P3.1 TASK-1 channel blocker. ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM). Based on potency differences, it possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related, two-pore domain potassium channel, TASK3. ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). Based on these criteria, ML365 is a best-in-class probe and is a useful pharmacological probe for in vitro studies of TASK1 function and in further studies aimed at developing therapeutic intervention.

ML365; ML-365; ML 365

Angiogenesis

CDK

TASK-1

Cardiovascular Disease

——

947914-18-3

360.41

C22H20N2O3

98%

DMSO : ≥ 100 mg/mL 277.46 mM H2O : < 0.1 mg/mL

COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1

2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

(-20℃)

With Ice Pack

≥ 2 years