ML364 ( ML 364;ML-364 )

Catalog No. M13111 CAS No. 1991986-30-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

ML364
Note

Research use only, not for human use.
Brief Description

A potent, selective, reversible deubiquitinase USP2 inhibitor with IC50 of 1.1 uM in biochemical assay.
Description

A potent, selective, reversible deubiquitinase USP2 inhibitor with IC50 of 1.1 uM in biochemical assay; also inhibits USP8 (IC50=0.95 uM), shows no against caspase 6/7, MMP1, MMP9 and USP15 and a panel of 102 kinase; increases cellular cyclin D1 degradation and causes cell cycle arrest and shows antiproliferative in cancer cell lines; also decreases homologous recombination-mediated DNA repair.
Synonyms

ML 364;ML-364
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

USP2
Research Area

Cancer
Indication

——

CAS Number

1991986-30-1
Formula Weight

517.54
Molecular Formula

C24H18F3N3O3S2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 33 mg/mL
SMILES

O=C(NC1=NC(C2=CC=CC=C2)=CS1)C3=CC=C(C(F)(F)F)C=C3NS(=O)(C4=CC=C(C)C=C4)=O
Chemical Name

Benzamide, 2-[[(4-methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)-

1. Davis MI, et al. J Biol Chem. 2016 Nov 18;291(47):24628-24640.

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