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Home - Products - GPCR/G Protein - Calcium Channel - ML335

ML335

CAS No. 825658-06-8

ML335( ML335 | ML-335 | ML 335 | TREK-1/2 Activator )

Catalog No. M17606 CAS No. 825658-06-8

ML335 is a selective activator of both TREK-1 and TREK-2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML335
  • Note
    Research use only, not for human use.
  • Brief Description
    ML335 is a selective activator of both TREK-1 and TREK-2.
  • Description
    ML335 is a potent and selective TREK-1/2 Activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.
  • In Vitro
    Xenopus oocyte two-electrode voltage-clamp measurements show that ML335 and ML402 activate K2P2.1 and K2P10.1 but not K2P4.1 (14.3±2.7?μM, K2P2.1-ML335; 13.7±7.0?μM, K2P2.1-ML402; 5.2±0.5?μM, K2P10.1-ML335; and 5.9±1.6?μM, K2P10.1-ML402). Swapping the Lys271 equivalent between K2P2.1 and K2P4.1 results in a clear phenotype reversal for ML335 and M402 activation. ML335 and ML402 activate K2P2.1 in HEK293 cells similar to their effects in Xenopus oocytes (5.2±0.8?μM and 5.9±1.6?μM for ML335 and ML402, respectively (n≥3)).
  • In Vivo
    ——
  • Synonyms
    ML335 | ML-335 | ML 335 | TREK-1/2 Activator
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    TREK-1| TREK-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    825658-06-8
  • Formula Weight
    373.25
  • Molecular Formula
    C15H14Cl2N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 155 mg/mL. 415.27 mM;
  • SMILES
    CS(=O)(=O)Nc1ccc(cc1)C(=O)NCc1c(cc(cc1)Cl)Cl
  • Chemical Name
    N-[(2,4-Dichlorophenyl)methyl]-4-(methanesulfonamido)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20;547(7663):364-368.
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