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Home - Products - Nuclear Receptor/Transcription Factor - Keap1-Nrf2 - ML334

ML334

CAS No. 1432500-66-7

ML334( —— )

Catalog No. M33029 CAS No. 1432500-66-7

ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ML334
  • Note
    Research use only, not for human use.
  • Brief Description
    ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation.
  • Description
    ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.
  • In Vitro
    RT-PCR Cell Line:HEK293 cells Concentration:50 μM or 100 μM Incubation Time:6 hours, 16 hours Result:Increased NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. Enhanced HO-1 mRNA expression between 4- and 7-fold at 6 h.Western Blot Analysis Cell Line:HEK293 cells Concentration:50 μM or 100 μM Incubation Time:16 hours Result:Enhanced HO-1 and TRX1 protein expression at 16 h.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    Keap1-Nrf2
  • Recptor
    Nrf2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1432500-66-7
  • Formula Weight
    446.49
  • Molecular Formula
    C26H26N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 44.65 mg/mL (100.00 mM; Ultrasonic )Ethanol : 44.65 mg/mL (100.00 mM; Ultrasonic)
  • SMILES
    OC(=O)[C@H]1CCCC[C@H]1C(=O)N1CCc2ccccc2[C@H]1CN1C(=O)c2ccccc2C1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wen X, et al. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol. 2015 Jun;29(6):261-6.?
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