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ML334
CAS No. 1432500-66-7
ML334( —— )
Catalog No. M33029 CAS No. 1432500-66-7
ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameML334
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NoteResearch use only, not for human use.
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Brief DescriptionML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation.
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DescriptionML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.
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In VitroRT-PCR Cell Line:HEK293 cells Concentration:50 μM or 100 μM Incubation Time:6 hours, 16 hours Result:Increased NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. Enhanced HO-1 mRNA expression between 4- and 7-fold at 6 h.Western Blot Analysis Cell Line:HEK293 cells Concentration:50 μM or 100 μM Incubation Time:16 hours Result:Enhanced HO-1 and TRX1 protein expression at 16 h.
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In Vivo——
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Synonyms——
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PathwayNuclear Receptor/Transcription Factor
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TargetKeap1-Nrf2
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RecptorNrf2
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Research Area——
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Indication——
Chemical Information
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CAS Number1432500-66-7
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Formula Weight446.49
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Molecular FormulaC26H26N2O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 44.65 mg/mL (100.00 mM; Ultrasonic )Ethanol : 44.65 mg/mL (100.00 mM; Ultrasonic)
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SMILESOC(=O)[C@H]1CCCC[C@H]1C(=O)N1CCc2ccccc2[C@H]1CN1C(=O)c2ccccc2C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wen X, et al. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol. 2015 Jun;29(6):261-6.?
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