ML328( —— )

Catalog No. M28826 CAS No. 634175-34-1

ML328 is a potent and selective inhibitor of bacterial AddAB(IC50 = 1.0 μM) and RecBCD(IC50 = 4.8 μM) helicase-nucleases.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

ML328
Note

Research use only, not for human use.
Brief Description

ML328 is a potent and selective inhibitor of bacterial AddAB(IC50 = 1.0 μM) and RecBCD(IC50 = 4.8 μM) helicase-nucleases.
Description

ML328 is a potent and selective inhibitor of bacterial AddAB(IC50 = 1.0 μM) and RecBCD(IC50 = 4.8 μM) helicase-nucleases.(In Vitro):The probe ML328 has a half-life of over 48 hours in PBS at room temperature when tested at 10 μM. Disappearance of the LC peak for the probe is unaltered by the addition of excess glutathione (50 μM) in a 6 hour incubation.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Bcl-2|Caspase-3
Research Area

——
Indication

——

Chemical Information

CAS Number

634175-34-1
Formula Weight

506.5
Molecular Formula

C22H21F3N6O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (49.36 mM)
SMILES

CCn1cc(C(O)=O)c(=O)c2cnc(nc12)N1CCN(CC1)C(=S)Nc1cccc(c1)C(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Yao H, et al. Thevetiaflavone from Wikstroemia indica ameliorates PC12 cells injury induced by OGD/R via improving ROS?mediated mitochondrial dysfunction. Mol Med Rep. 2017 Dec;16(6):9197-9202.

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