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ML265

CAS No. 1221186-53-3

ML265 ( TEPP-46 )

Catalog No. M20635 CAS No. 1221186-53-3

ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1 PKL and PKRinduces tetramerization and reduces tumor formation and size in a mouse xenograft model.?.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML265
  • Note
    Research use only not for human use.
  • Brief Description
    ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1 PKL and PKRinduces tetramerization and reduces tumor formation and size in a mouse xenograft model.?.
  • Description
    ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1 PKL and PKRinduces tetramerization and reduces tumor formation and size in a mouse xenograft model.?
  • Synonyms
    TEPP-46
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PKM2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1221186-53-3
  • Formula Weight
    372.46
  • Molecular Formula
    C17H16N4O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (134.24 mM)
  • SMILES
    Cn1c2cc(sc2c2cnn(Cc3cccc(N)c3)c(=O)c12)S(C)=O
  • Chemical Name
    6-(3-aminobenzyl)-4-methyl-2-(methylsulfinyl)-46-dihydro-5H-thieno[2'3':45]pyrrolo[23-d]pyridazin-5-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Walsh M J Brimacombe K R Anastasiou D et al. ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model[M]// Probe Reports from the NIH Molecular Libraries Program. PubMed 2009.
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