ML265 ( TEPP-46 )

Catalog No. M20635 CAS No. 1221186-53-3

ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1 PKL and PKRinduces tetramerization and reduces tumor formation and size in a mouse xenograft model.?.

Purity : >98% (HPLC)

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Biological Information

Product Name

ML265
Note

Research use only not for human use.
Brief Description

ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1 PKL and PKRinduces tetramerization and reduces tumor formation and size in a mouse xenograft model.?.
Description

ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1 PKL and PKRinduces tetramerization and reduces tumor formation and size in a mouse xenograft model.?
Synonyms

TEPP-46
Pathway

Others
Target

Other Targets
Recptor

PKM2
Research Area

——
Indication

——

Chemical Information

CAS Number

1221186-53-3
Formula Weight

372.46
Molecular Formula

C17H16N4O2S2
Purity

>98% (HPLC)
Solubility

DMSO:50 mg/mL (134.24 mM)
SMILES

Cn1c2cc(sc2c2cnn(Cc3cccc(N)c3)c(=O)c12)S(C)=O
Chemical Name

6-(3-aminobenzyl)-4-methyl-2-(methylsulfinyl)-46-dihydro-5H-thieno[2'3':45]pyrrolo[23-d]pyridazin-5-one

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Walsh M J Brimacombe K R Anastasiou D et al. ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model[M]// Probe Reports from the NIH Molecular Libraries Program. PubMed 2009.

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