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ML251

CAS No. 1486482-16-9

ML251( ML251? )

Catalog No. M26000 CAS No. 1486482-16-9

ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML251
  • Note
    Research use only, not for human use.
  • Brief Description
    ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase.
  • Description
    ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite.(In Vitro):ML251 produces modest dose-dependent toxicity.
  • In Vitro
    ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity. Cell Cytotoxicity Assay Cell Line:T. brucei Concentration:0~33.3 μg/mL Incubation Time:Result:Dose-dependent reduction of cell viability.
  • In Vivo
    ——
  • Synonyms
    ML251?
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Glucokinase
  • Recptor
    p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1486482-16-9
  • Formula Weight
    426.27
  • Molecular Formula
    C17H13Cl2N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (586.48 mM)
  • SMILES
    O=C(Cc(cc1)cc(Cl)c1Cl)Nc(cc1)ccc1S(Nc1nocc1)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87.
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  • ML251

    ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase.

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