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Home - Products - PI3K/Akt/mTOR signaling - mTOR - ML239

ML239

CAS No. 1378872-36-6

ML239( —— )

Catalog No. M17266 CAS No. 1378872-36-6

ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML239
  • Note
    Research use only, not for human use.
  • Brief Description
    ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
  • Description
    ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
  • In Vitro
    ML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ～24-fold selectivity against the control cell line. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    Others
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1378872-36-6
  • Formula Weight
    346.59
  • Molecular Formula
    C13H10Cl3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 300 mg/mL 865.55 mM
  • SMILES
    Clc2cc(Cl)cc(Cl)c2OCC(=O)N\N=C\c1cccn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Germain AR,etal.Identification of a selective small molecule inhibitor of breast cancer stem cells.Bioorg Med Chem Lett. 2012 May 15;22(10):3571-4.
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