ML221
CAS No. 877636-42-5
ML221 ( ML221; ML 221; ML-221 )
Catalog No. M17640 CAS No. 877636-42-5
ML221 is a potentapelin /APJfunctional antagonist, inhibiting apelin-13-mediated activation of APJ, withIC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, andEC80of 10 nM in both assays.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 45 | In Stock |
|
10MG | 70 | In Stock |
|
25MG | 152 | In Stock |
|
50MG | 231 | In Stock |
|
100MG | 421 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameML221
-
NoteResearch use only, not for human use.
-
Brief DescriptionML221 is a potentapelin /APJfunctional antagonist, inhibiting apelin-13-mediated activation of APJ, withIC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, andEC80of 10 nM in both assays.
-
DescriptionML221 is a potentapelin /APJfunctional antagonist, inhibiting apelin-13-mediated activation of APJ, withIC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, andEC80of 10 nM in both assays.
-
SynonymsML221; ML 221; ML-221
-
PathwayOthers
-
TargetOther Targets
-
RecptorAPJ
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number877636-42-5
-
Formula Weight385.35
-
Molecular FormulaC17H11N3O6S
-
Purity98%
-
SolubilityDMSO : ≥ 31 mg/mL; 80.45 mM
-
SMILESC1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
-
Chemical Name[4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Maloney PR, etal.Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60.
molnova catalog
related products
-
Sincalide ammonium
Sincalide ammonium (Cholecystokinin octapeptide ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography.
-
GSK J1
GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively.
-
TAT-amide
TAT-amide is a cell penetrating peptide. Cell-penetrating peptides (CPPs) are short amino acid sequences able to enter different cells.