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ML221
CAS No. 877636-42-5
ML221( ML221 | ML 221 | ML-221 )
Catalog No. M17640 CAS No. 877636-42-5
ML221 is a potent?apelin /APJ?functional antagonist, inhibiting apelin-13-mediated activation of APJ, with?IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and?EC80?of 10 nM in both assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 45 | In Stock |
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| 10MG | 70 | In Stock |
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| 25MG | 152 | In Stock |
|
| 50MG | 231 | In Stock |
|
| 100MG | 421 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML221
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NoteResearch use only, not for human use.
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Brief DescriptionML221 is a potent?apelin /APJ?functional antagonist, inhibiting apelin-13-mediated activation of APJ, with?IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and?EC80?of 10 nM in both assays.
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DescriptionML221 is a potent?apelin /APJ?functional antagonist, inhibiting apelin-13-mediated activation of APJ, with?IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and?EC80?of 10 nM in both assays.
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In Vitro——
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In Vivo——
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SynonymsML221 | ML 221 | ML-221
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PathwayOthers
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TargetOther Targets
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RecptorAPJ
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number877636-42-5
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Formula Weight385.35
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Molecular FormulaC17H11N3O6S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 31 mg/mL; 80.45 mM
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SMILESC1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
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Chemical Name[4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Maloney PR, etal.Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60.
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