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ML221

CAS No. 877636-42-5

ML221( ML221 | ML 221 | ML-221 )

Catalog No. M17640 CAS No. 877636-42-5

ML221 is a potent?apelin /APJ?functional antagonist, inhibiting apelin-13-mediated activation of APJ, with?IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and?EC80?of 10 nM in both assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML221
  • Note
    Research use only, not for human use.
  • Brief Description
    ML221 is a potent?apelin /APJ?functional antagonist, inhibiting apelin-13-mediated activation of APJ, with?IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and?EC80?of 10 nM in both assays.
  • Description
    ML221 is a potent?apelin /APJ?functional antagonist, inhibiting apelin-13-mediated activation of APJ, with?IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and?EC80?of 10 nM in both assays.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ML221 | ML 221 | ML-221
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    APJ
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    877636-42-5
  • Formula Weight
    385.35
  • Molecular Formula
    C17H11N3O6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 31 mg/mL; 80.45 mM
  • SMILES
    C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
  • Chemical Name
    [4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Maloney PR, etal.Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60.
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