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ML141
CAS No. 71203-35-5
ML141( CID2950007 )
Catalog No. M15727 CAS No. 71203-35-5
ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 59 | In Stock |
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| 10MG | 101 | In Stock |
|
| 25MG | 212 | In Stock |
|
| 50MG | 385 | In Stock |
|
| 100MG | 551 | In Stock |
|
| 500MG | 1188 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameML141
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NoteResearch use only, not for human use.
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Brief DescriptionML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
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DescriptionML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
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In VitroML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively. ML141 inhibits 3T3 fibroblast filopodia formation and inhibits ovarian cancer cell migration.
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In VivoML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice. Animal Model:C57Bl/6J mice Dosage:10 μM Administration:Intracerebroventricular injection Result:Increased anxiety in mice.
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SynonymsCID2950007
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PathwayAngiogenesis
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TargetCDK
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Recptorcdc42
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number71203-35-5
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Formula Weight407.49
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Molecular FormulaC22H21N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 81 mg/mL warmed (198.77 mM)
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SMILESO=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)C=C1)(N)=O
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Chemical Name4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen HY, et al. EMBO Mol Med. 2013, 5(5), 723-736.
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