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Home - Products - MAPK/ERK Signaling - Ras - ML-210

ML-210

CAS No. 1360705-96-9

ML-210( ML 210 | ML210 )

Catalog No. M11484 CAS No. 1360705-96-9

A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 Get Quote
5MG 71 Get Quote
10MG 129 Get Quote
25MG 233 Get Quote
50MG 393 Get Quote
100MG 566 Get Quote
200MG 803 Get Quote
500MG 1188 Get Quote
1G Get Quote Get Quote
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Biological Information

  • Product Name
    ML-210
  • Note
    Research use only, not for human use.
  • Brief Description
    A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.
  • Description
    A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ML 210 | ML210
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    Ras
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1360705-96-9
  • Formula Weight
    475.32
  • Molecular Formula
    C22H20Cl2N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (52.60 mM)
  • SMILES
    O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O
  • Chemical Name
    (4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. We?wer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.
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