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ML-162
CAS No. 1035072-16-2
ML-162( ML 162 | ML162 )
Catalog No. M10173 CAS No. 1035072-16-2
A small-molecule probe that selectively kills cells induced to express mutant RAS.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 82 | Get Quote |
|
| 10MG | 127 | Get Quote |
|
| 25MG | 267 | Get Quote |
|
| 50MG | 434 | Get Quote |
|
| 100MG | 532 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameML-162
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NoteResearch use only, not for human use.
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Brief DescriptionA small-molecule probe that selectively kills cells induced to express mutant RAS.
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DescriptionA small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.
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In Vitro——
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In Vivo——
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SynonymsML 162 | ML162
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorRas
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Research Area——
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Indication——
Chemical Information
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CAS Number1035072-16-2
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Formula Weight477.4
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Molecular FormulaC23H22CI2N2O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (209.47 mM)
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SMILESCOC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl
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Chemical Name2-chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. We?wer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.
2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program.
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