ML-109

CAS No. 1186649-91-1

ML-109( —— )

Catalog No. M21973 CAS No. 1186649-91-1

ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM,has no activity at FSHR or LHCGR.

ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM,has no activity at FSHR or LHCGR.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 39 In Stock
5MG 65 In Stock
10MG 110 In Stock
25MG 222 In Stock
50MG 356 In Stock
100MG 533 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    ML-109
  • Note
    Research use only, not for human use.
  • Brief Description
    ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM,has no activity at FSHR or LHCGR.
  • Description
    ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM ,has no activity at FSHR or LHCGR.
  • In Vitro
    ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    thyrotropin receptor (TSHR)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1186649-91-1
  • Formula Weight
    523.58
  • Molecular Formula
    C31H29N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:83.33 mg/mL (159.15 mM; Need ultrasonic)
  • SMILES
    COc1ccc(cc1COc1ccc(NC(C)=O)cc1)C1Nc2cccc(O)c2C(=O)N1Cc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6.
molnova catalog
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