ML-109
CAS No. 1186649-91-1
ML-109( —— )
Catalog No. M21973 CAS No. 1186649-91-1
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM,has no activity at FSHR or LHCGR.
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM,has no activity at FSHR or LHCGR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 39 | In Stock |
|
5MG | 65 | In Stock |
|
10MG | 110 | In Stock |
|
25MG | 222 | In Stock |
|
50MG | 356 | In Stock |
|
100MG | 533 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameML-109
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NoteResearch use only, not for human use.
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Brief DescriptionML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM,has no activity at FSHR or LHCGR.
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DescriptionML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM ,has no activity at FSHR or LHCGR.
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In VitroML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h).
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorthyrotropin receptor (TSHR)
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Research Area——
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Indication——
Chemical Information
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CAS Number1186649-91-1
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Formula Weight523.58
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Molecular FormulaC31H29N3O5
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL (159.15 mM; Need ultrasonic)
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SMILESCOc1ccc(cc1COc1ccc(NC(C)=O)cc1)C1Nc2cccc(O)c2C(=O)N1Cc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6.
molnova catalog
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