ML-109

Research use only, not for human use.

ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM,has no activity at FSHR or LHCGR.

ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM ,has no activity at FSHR or LHCGR.

ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h).

——

——

Others

Other Targets

thyrotropin receptor (TSHR)

——

——

1186649-91-1

523.58

C31H29N3O5

>98% (HPLC)

DMSO:83.33 mg/mL (159.15 mM; Need ultrasonic)

COc1ccc(cc1COc1ccc(NC(C)=O)cc1)C1Nc2cccc(O)c2C(=O)N1Cc1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years