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ML 154
CAS No. 1345964-89-7
ML 154( NCGC84 )
Catalog No. M27660 CAS No. 1345964-89-7
ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 69 | In Stock |
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| 5MG | 107 | In Stock |
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| 10MG | 151 | In Stock |
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| 25MG | 278 | In Stock |
|
| 50MG | 390 | In Stock |
|
| 100MG | 539 | In Stock |
|
| 200MG | 728 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML 154
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NoteResearch use only, not for human use.
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Brief DescriptionML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
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DescriptionML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
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In VitroWestern Blot Analysis Cell Line:CHO cells expressing NPSR Concentration:0.001 μM, 0.01 μM, 0.1 μM, 1 μM Incubation Time:30 min Result:Exhibited the most potent inhibition on NPS-induced ERK phosphorylation.
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In VivoAnimal Model:Male Wistar rats (300-350 g) injected with alcohol Dosage:1 mg/kg (10% Solutol, 10% N,N-dimethylacetamide, and 80% 10 mM PBS, pH 7.4) Administration:Intraperitoneal injection; once Result:Inhibited alcohol-induced central ERK phosphorylation in vivo.
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SynonymsNCGC84
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PathwayGPCR/G Protein
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TargetNeuropeptide Y Receptor
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RecptorG2019S LRRK2
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Research Area——
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Indication——
Chemical Information
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CAS Number1345964-89-7
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Formula Weight545.48
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Molecular FormulaC29H26BrN2PS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (114.58 mM)
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SMILES[Br-].Cc1c([n+]2ccccc2n1C\C=C\c1ccccc1)P(=S)(c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63(23):14821-14839.
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