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MKC8866

CAS No. 1338934-59-0

MKC8866 ( —— )

Catalog No. M23496 CAS No. 1338934-59-0

MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29?μM in human vitro).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	177	In Stock
10MG	288	In Stock
25MG	484	In Stock
50MG	701	In Stock
100MG	981	In Stock
500MG	1962	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

MKC8866
Note

Research use only, not for human use.
Brief Description

MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29?μM in human vitro).
Description

MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29?μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

IRE1 RNase
Research Area

——
Indication

——

Chemical Information

CAS Number

1338934-59-0
Formula Weight

361.4
Molecular Formula

C18H19NO7
Purity

>98% (HPLC)
Solubility

DMSO:16.67 mg/mL (46.13 mM; Need ultrasonic)
SMILES

O=CC1=C(O)C(OC)=CC2=C1OC(C(CC(N3CCOCC3)=O)=C2C)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Sheng X, et al. IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nat Commun. 2019 Jan 24;10(1):323.

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