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MKC-733
CAS No. 194093-42-0
MKC-733 ( MKC733;Pumosetrag;DDP 733 )
Catalog No. M13042 CAS No. 194093-42-0
A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMKC-733
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.
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DescriptionA potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors; dose dependently stimulates contraction and basal electrolyte secretion in the isolated guinea pig colon, effects that are antagonized by the selective 5-HT3 antagonist ondansetron, also accelerates gastric emptying in some animal models.Irritable Bowel Syndrome Phase 2 Discontinued
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SynonymsMKC733;Pumosetrag;DDP 733
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaOther Indications
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IndicationIrritable Bowel Syndrome
Chemical Information
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CAS Number194093-42-0
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Formula Weight39.84
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Molecular FormulaC15H18ClN3O2S
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Purity>98% (HPLC)
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SolubilityDMSO : 30 mg/mL 88.28 mM
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SMILESO=C(C1=CNC(C=CS2)=C2C1=O)N[C@H]3CN4CCC3CC4.[H]Cl
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Chemical NameThieno[3,2-b]pyridine-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-, monohydrochloride (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Coleman NS, et al. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48.
2. Fujita T, et al.
3. Chetty N, et al. Pharmacology. 2008;81(2):104-9.
4. Choung RS, et al. Neurogastroenterol Motil. 2014 Jan;26(1):13-20.
2. Fujita T, et al.
3. Chetty N, et al. Pharmacology. 2008;81(2):104-9.
4. Choung RS, et al. Neurogastroenterol Motil. 2014 Jan;26(1):13-20.
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