MKC-733

Research use only, not for human use.

A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.

A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors; dose dependently stimulates contraction and basal electrolyte secretion in the isolated guinea pig colon, effects that are antagonized by the selective 5-HT3 antagonist ondansetron, also accelerates gastric emptying in some animal models.Irritable Bowel Syndrome Phase 2 Discontinued

MKC733;Pumosetrag;DDP 733

Endocrinology/Hormones

5-HT Receptor

5-HT Receptor

Other Indications

Irritable Bowel Syndrome

194093-42-0

39.84

C15H18ClN3O2S

>98% (HPLC)

DMSO : 30 mg/mL 88.28 mM

O=C(C1=CNC(C=CS2)=C2C1=O)N[C@H]3CN4CCC3CC4.[H]Cl

Thieno[3,2-b]pyridine-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-, monohydrochloride (9CI)

(-20℃)

With Ice Pack

≥ 2 years