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MK5046
CAS No. 1022152-70-0
MK5046( —— )
Catalog No. M10106 CAS No. 1022152-70-0
MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 160 | In Stock |
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| 10MG | 260 | In Stock |
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| 25MG | 497 | In Stock |
|
| 50MG | 714 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK5046
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NoteResearch use only, not for human use.
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Brief DescriptionMK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity.
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DescriptionMK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).
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In Vitro——
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In VivoAnimal Model:Male C57BL/6N mice with high-fat diet for the diet-induced obese (DIO) modelDosage:3, 10 and 30 mg/kg.Administration:Oral administration; 3, 10 and 30 mg/kg for once Result:Dose-dependently inhibited food intake at 2 h and overnight in DIO mice. But showed no effect on Brs3 knockout mice.
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Synonyms——
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PathwayGPCR/G Protein
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TargetBombesin Receptor
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RecptorBRS-3
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number1022152-70-0
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Formula Weight444.37
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Molecular FormulaC20H18F6N4O
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESC1CC1(CC2=CN=C(N2)C[C@](C3=CC=C(C=C3)N4C=CC=N4)(C(F)(F)F)O)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Guan XM, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):356-364.
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