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MK-8825

CAS No. 1380887-60-4

MK-8825 ( MK8825 )

Catalog No. M11576 CAS No. 1380887-60-4

MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    MK-8825
  • Note
    Research use only, not for human use.
  • Brief Description
    MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
  • Description
    MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM; possesses significantly improved in vivo potency in rat pharmacodynamic models.Migraine Phase 1 Clinical
  • Synonyms
    MK8825
  • Pathway
    GPCR/G Protein
  • Target
    CGRP Receptor
  • Recptor
    CGRP Receptor
  • Research Area
    Neurological Disease
  • Indication
    Migraine

Chemical Information

  • CAS Number
    1380887-60-4
  • Formula Weight
    572.62
  • Molecular Formula
    C31H30F2N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1(CNC2(CCCC2)C(=O)N1CC(=O)NC3=CC4=C(CC5(C4)C6=C(NC5=O)N=CC=C6)N=C3)C7=CC(=CC(=C7)F)F
  • Chemical Name
    2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(6S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-3-yl]acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bell IM, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3941-5.
2. Michot B, et al. Eur J Pain. 2015 Feb;19(2):281-90.
3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep;271:95-103.
4. Feistel S, et al. J Headache Pain. 2013 Nov 20;14:93.
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