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MK-8825
CAS No. 1380887-60-4
MK-8825( MK8825 )
Catalog No. M11576 CAS No. 1380887-60-4
MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1773 | Get Quote |
|
| 50MG | 3582 | Get Quote |
|
| 100MG | 4950 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMK-8825
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NoteResearch use only, not for human use.
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Brief DescriptionMK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
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DescriptionMK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM; possesses significantly improved in vivo potency in rat pharmacodynamic models.Migraine Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsMK8825
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PathwayGPCR/G Protein
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TargetCGRP Receptor
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RecptorCGRP Receptor
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Research AreaNeurological Disease
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IndicationMigraine
Chemical Information
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CAS Number1380887-60-4
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Formula Weight572.617
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Molecular FormulaC31H30F2N6O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1(CNC2(CCCC2)C(=O)N1CC(=O)NC3=CC4=C(CC5(C4)C6=C(NC5=O)N=CC=C6)N=C3)C7=CC(=CC(=C7)F)F
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Chemical Name2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(6S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-3-yl]acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bell IM, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3941-5.
2. Michot B, et al. Eur J Pain. 2015 Feb;19(2):281-90.
3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep;271:95-103.
4. Feistel S, et al. J Headache Pain. 2013 Nov 20;14:93.
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