MK-4618 ( MK 4618;MK4618;Vibegron;KRP-114V;RVT-901 )

Catalog No. M10653 CAS No. 1190389-15-1

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Product Name

MK-4618
Note

Research use only, not for human use.
Brief Description

A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM; displays no activity for β1 and β2 receptors (EC50>20 uM).
Description

A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM; displays no activity for β1 and β2 receptors (EC50>20 uM); dose-dependently increases bladder capacity, decreased micturition pressure, and increased bladder compliance in rhesus monkeys, dose-dependently increases the circulating glycerol and fatty acid levels in rhesus and rat in vivo; shows the potential for treatment of overactive bladder with M2/M3 antimuscarinics.Other Indication Phase 3 Clinical
Synonyms

MK 4618;MK4618;Vibegron;KRP-114V;RVT-901
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

Other Indications
Indication

Other Disease

CAS Number

1190389-15-1
Formula Weight

444.54
Molecular Formula

C26H28N4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C([C@@H]1CCC2=NC=CC(N21)=O)NC3=CC=C(C[C@H]4N[C@@H]([C@H](O)C5=CC=CC=C5)CC4)C=C3
Chemical Name

(S)-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide

1. Edmondson SD, et al. J Med Chem. 2016 Jan 28;59(2):609-23.
2. Di Salvo J, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):346-355.

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