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MID-1

CAS No. 312608-54-1

MID-1 ( —— )

Catalog No. M22748 CAS No. 312608-54-1

MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.?It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 147 In Stock
10MG 222 In Stock
25MG 410 In Stock
50MG 605 In Stock
100MG 860 In Stock
500MG 1728 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    MID-1
  • Note
    Research use only, not for human use.
  • Brief Description
    MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.?It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.
  • Description
    MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.?It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MG53-IRS-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    312608-54-1
  • Formula Weight
    293.3
  • Molecular Formula
    C12H11N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31.25 mg/mL?(106.55 mM;?Need ultrasonic)
  • SMILES
    CCOc1ccc(cc1)C(=O)Nc1ncc(s1)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635.
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