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MID-1

CAS No. 312608-54-1

MID-1 ( —— )

Catalog No. M22748 CAS No. 312608-54-1

MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.?It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 147 In Stock
10MG 222 In Stock
25MG 410 In Stock
50MG 605 In Stock
100MG 860 In Stock
500MG 1728 In Stock
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Biological Information

  • Product Name
    MID-1
  • Note
    Research use only, not for human use.
  • Brief Description
    MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.?It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.
  • Description
    MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.?It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MG53-IRS-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    312608-54-1
  • Formula Weight
    293.3
  • Molecular Formula
    C12H11N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31.25 mg/mL?(106.55 mM;?Need ultrasonic)
  • SMILES
    CCOc1ccc(cc1)C(=O)Nc1ncc(s1)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635.
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