MGL-3196

CAS No. 920509-32-6

MGL-3196( Resmetirom | VIA-3196 | MGL3196 | MGL 3196 | VIA3196 | VIA 3196 )

Catalog No. M16604 CAS No. 920509-32-6

MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 42 In Stock
5MG 80 In Stock
10MG 115 In Stock
25MG 203 In Stock
50MG 324 In Stock
100MG 482 In Stock
500MG 1071 In Stock
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Biological Information

  • Product Name
    MGL-3196
  • Note
    Research use only, not for human use.
  • Brief Description
    MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM
  • Description
    MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM; shows 28-fold selectivity for THR-β over THR-α in a functional assay; exhibits an excellent safety profile and orally bioactive.Steatohepatitis,Phase 2 Clinical(In Vitro):Resmetirom (MGL-3196) is 28-fold selective for THR-β (EC50=0.21 μM) over THR-α (EC50=3.74 μM ) in a functional assay. Resmetirom (MGL-3196) shows an IC20 of roughly 30 μM for blockage of the hERG channel. The IC50 for CYP3A4/5 and for CYP2C19 is >50 μM, and there is only weak inhibition (roughly 22 μM) of CYP2C9.(In Vivo):Resmetirom (MGL-3196) exhibits good exposures and reasonable oral bioavailability in rats. The volume of distribution and clearance are both low. Dose proportional increases in exposure are observed for a suspension of Resmetirom (MGL-3196) given orally to DIO mice.In animals treated with Resmetirom (MGL-3196) there is a reduction in cholesterol and in liver size, which is secondary to reduction of liver TG. There is no effect on bone mineral density (BMD) or heart or kidney size in Resmetirom (MGL-3196) treated animals.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Resmetirom | VIA-3196 | MGL3196 | MGL 3196 | VIA3196 | VIA 3196
  • Pathway
    Endocrinology/Hormones
  • Target
    THR
  • Recptor
    THR-β
  • Research Area
    Other Indications
  • Indication
    Steatohepatitis

Chemical Information

  • CAS Number
    920509-32-6
  • Formula Weight
    435.221
  • Molecular Formula
    C17H12Cl2N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O
  • Chemical Name
    1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kelly MJ, et al. J Med Chem. 2014 May 22;57(10):3912-23.
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