MGL-3196 ( Resmetirom;VIA-3196;MGL3196;MGL 3196;VIA3196;VIA 3196 )

Catalog No. M16604 CAS No. 920509-32-6

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Product Name

MGL-3196
Note

Research use only, not for human use.
Brief Description

MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM
Description

MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM; shows 28-fold selectivity for THR-β over THR-α in a functional assay; exhibits an excellent safety profile and orally bioactive.Steatohepatitis,Phase 2 Clinical
Synonyms

Resmetirom;VIA-3196;MGL3196;MGL 3196;VIA3196;VIA 3196
Pathway

Endocrinology/Hormones
Target

THR
Recptor

THR-β
Research Area

Other Indications
Indication

Steatohepatitis

CAS Number

920509-32-6
Formula Weight

435.22
Molecular Formula

C17H12Cl2N6O4
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 31 mg/mL
SMILES

N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O
Chemical Name

1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-

1. Kelly MJ, et al. J Med Chem. 2014 May 22;57(10):3912-23.

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