
MGL-3196
CAS No. 920509-32-6
MGL-3196( Resmetirom | VIA-3196 | MGL3196 | MGL 3196 | VIA3196 | VIA 3196 )
Catalog No. M16604 CAS No. 920509-32-6
MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM
Purity : >98% (HPLC)






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2MG | 42 | In Stock |
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5MG | 80 | In Stock |
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10MG | 115 | In Stock |
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25MG | 203 | In Stock |
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50MG | 324 | In Stock |
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100MG | 482 | In Stock |
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500MG | 1071 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameMGL-3196
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NoteResearch use only, not for human use.
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Brief DescriptionMGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM
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DescriptionMGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM; shows 28-fold selectivity for THR-β over THR-α in a functional assay; exhibits an excellent safety profile and orally bioactive.Steatohepatitis,Phase 2 Clinical(In Vitro):Resmetirom (MGL-3196) is 28-fold selective for THR-β (EC50=0.21 μM) over THR-α (EC50=3.74 μM ) in a functional assay. Resmetirom (MGL-3196) shows an IC20 of roughly 30 μM for blockage of the hERG channel. The IC50 for CYP3A4/5 and for CYP2C19 is >50 μM, and there is only weak inhibition (roughly 22 μM) of CYP2C9.(In Vivo):Resmetirom (MGL-3196) exhibits good exposures and reasonable oral bioavailability in rats. The volume of distribution and clearance are both low. Dose proportional increases in exposure are observed for a suspension of Resmetirom (MGL-3196) given orally to DIO mice.In animals treated with Resmetirom (MGL-3196) there is a reduction in cholesterol and in liver size, which is secondary to reduction of liver TG. There is no effect on bone mineral density (BMD) or heart or kidney size in Resmetirom (MGL-3196) treated animals.
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In Vitro——
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In Vivo——
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SynonymsResmetirom | VIA-3196 | MGL3196 | MGL 3196 | VIA3196 | VIA 3196
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PathwayEndocrinology/Hormones
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TargetTHR
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RecptorTHR-β
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Research AreaOther Indications
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IndicationSteatohepatitis
Chemical Information
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CAS Number920509-32-6
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Formula Weight435.221
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Molecular FormulaC17H12Cl2N6O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 31 mg/mL
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SMILESN#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O
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Chemical Name1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kelly MJ, et al. J Med Chem. 2014 May 22;57(10):3912-23.
molnova catalog



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