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MELK-T1
CAS No. 1610586-62-3
MELK-T1( —— )
Catalog No. M12325 CAS No. 1610586-62-3
A novel, cell-permeable, potent and selective inhibitor of MELK kinase domain with IC50 of 37 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMELK-T1
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NoteResearch use only, not for human use.
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Brief DescriptionA novel, cell-permeable, potent and selective inhibitor of MELK kinase domain with IC50 of 37 nM.
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DescriptionA novel, cell-permeable, potent and selective inhibitor of MELK kinase domain with IC50 of 37 nM; shows >50% inhibition at 1 uM against 6 kianses in a panel of 235 kinases (Flt3 IC50=18 nM); triggers a rapid and proteasome-dependent degradation of the MELK protein, induces the accumulation of stalled replication forks and DSBs in MCF-7 cells; induces a strong phosphorylation of p53, a prolonged up-regulation of p21 and a down-regulation of FOXM1 target genes.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetMELK
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RecptorMELK
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Research Area——
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Indication——
Chemical Information
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CAS Number1610586-62-3
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Formula Weight362.433
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Molecular FormulaC21H22N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=C(C=CC(=C1)C2=CNN=C2)C(=O)NC3=CC4=C(CCNCC4)C=C3
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Chemical Name2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beke L, et al. Biosci Rep. 2015 Oct 2;35(6). pii: e00267.
2. Johnson CN, et al. ACS Med Chem Lett. 2014 May 23;6(1):25-30.
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