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MEISi-2

CAS No. 2250156-71-7

MEISi-2( Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide )

Catalog No. M24027 CAS No. 2250156-71-7

MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MEISi-2
  • Note
    Research use only, not for human use.
  • Brief Description
    MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.
  • Description
    MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.
  • In Vitro
    MEISi-2 does not significantly inhibit the PBX-Luc-reporter.MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal.MEISi-2 down-regulates MEIS target gene expression.MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo.
  • In Vivo
    MEISi-2 (10?μM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content.MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF. Animal Model:4-6 week-old BALB/c mice Dosage:10?μM/100?μL Administration:Intraperitoneal injection, at day 1, day 4 and day 7 Result:Modulated HSC pool.
  • Synonyms
    Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MEIS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2250156-71-7
  • Formula Weight
    306.32
  • Molecular Formula
    C18H14N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : < 0.1 mg/mL (insoluble))
  • SMILES
    O=C(NN/C=C1C(C=CC2=C\1C=CC=C2)=O)C3=CC=C(O)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Turan R D , Albayrak E , Uslu M , et al. Development of Small Molecule MEIS Inhibitors that modulate HSC activity[J]. Scientific Reports.
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