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MD2-IN-1
CAS No. 111797-22-9
MD2-IN-1 ( MD2-IN-1; MDK7229; MDK 7229; MDK 7229. )
Catalog No. M17145 CAS No. 111797-22-9
MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 161 | In Stock |
|
| 10MG | 266 | In Stock |
|
| 25MG | 478 | In Stock |
|
| 50MG | 691 | In Stock |
|
| 100MG | 963 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMD2-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionMD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).
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DescriptionMDK7229, also known as MD2-IN-1 is a MD2 (Myeloid differentiation protein 2) inhibitor. MDK7229 has CAS#111797-22-9. For easy communication, we use its last 4 digit of CAS for name. MDK7229 locked the LPS-induced activation of TLR4/MD2 -downstream pro-inflammatory MAPKs/NF-κB signaling pathways. In a rat model with ALI induced by intracheal LPS instillation, administration MDK7229 exhibited significant protective effect against ALI, accompanied by the inhibition of TLR4/MD2 complex formation in lung tissues.
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SynonymsMD2-IN-1; MDK7229; MDK 7229; MDK 7229.
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PathwayOthers
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TargetOther Targets
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RecptorMyeloid differentiation protein 2(MD2)
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number111797-22-9
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Formula Weight358.39
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Molecular FormulaC20H22O6
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Purity98%
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SolubilityDMSO : 50 mg/mL 139.51 mM; H2O : < 0.1 mg/mL
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SMILESCOc1ccc(cc1OC)C(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
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Chemical Name(E)-1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang Y, et al. Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury. Sci Rep. 2016 Apr 27;6:25130.
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