Cart
sales@molnova.com
Home - Products - Others - Other Targets - MD2-IN-1

MD2-IN-1

CAS No. 111797-22-9

MD2-IN-1 ( MD2-IN-1; MDK7229; MDK 7229; MDK 7229. )

Catalog No. M17145 CAS No. 111797-22-9

MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 161 In Stock
10MG 266 In Stock
25MG 478 In Stock
50MG 691 In Stock
100MG 963 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    MD2-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).
  • Description
    MDK7229, also known as MD2-IN-1 is a MD2 (Myeloid differentiation protein 2) inhibitor. MDK7229 has CAS#111797-22-9. For easy communication, we use its last 4 digit of CAS for name. MDK7229 locked the LPS-induced activation of TLR4/MD2 -downstream pro-inflammatory MAPKs/NF-κB signaling pathways. In a rat model with ALI induced by intracheal LPS instillation, administration MDK7229 exhibited significant protective effect against ALI, accompanied by the inhibition of TLR4/MD2 complex formation in lung tissues.
  • Synonyms
    MD2-IN-1; MDK7229; MDK 7229; MDK 7229.
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Myeloid differentiation protein 2(MD2)
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    111797-22-9
  • Formula Weight
    358.39
  • Molecular Formula
    C20H22O6
  • Purity
    98%
  • Solubility
    DMSO : 50 mg/mL 139.51 mM; H2O : < 0.1 mg/mL
  • SMILES
    COc1ccc(cc1OC)C(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
  • Chemical Name
    (E)-1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang Y, et al. Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury. Sci Rep. 2016 Apr 27;6:25130.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Ertugliflozin L-pyro...

    Ertugliflozin L-pyroglutamic acid is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM.

  • Furimazine

    Furimazine is an imidazopyrazinone substrate. NanoLuc (Nluc) paired with Furimazine produced 2.5 million-fold brighter luminescence in mammalian cells relative to Oluc-19 with Coelenterazine.

  • RI-STAD 2

    AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.

Sign In Join Free