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MCU-i11

CAS No. 902903-59-7

MCU-i11 ( —— )

Catalog No. M28985 CAS No. 902903-59-7

MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MCU-i11
  • Note
    Research use only, not for human use.
  • Brief Description
    MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
  • Description
    MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.(In Vitro):Mitochondrial Ca2+ uptake in mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines were measured upon treatment with 10 μM compound. MCU-i11 reduced mitochondrial Ca2+ uptake in all tested cell lines, indicating the existence of a conserved mechanism. MCU-i11 had no effect on cell viability.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PI3Kδ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    902903-59-7
  • Formula Weight
    532.6
  • Molecular Formula
    C28H28N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCOC1=CC=C(NC(=O)CN2C3=C(C4=C(CN(CC4)C(C)=O)S3)C(=O)N(CC3=CC=CC=C3)C2=O)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Li F, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993.
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