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MCT1-IN-3

CAS No. 2878360-80-4

MCT1-IN-3( —— )

Catalog No. M35939 CAS No. 2878360-80-4

MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MCT1-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment.
  • Description
    MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1)inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer.
  • In Vitro
    Cell Cycle AnalysisCell Line:A-549 cells Concentration:5 μM Incubation Time:24 h Result:Caused a disruption of the cell cycle of A-549 cancer cells, indicated by a shift from the predominant Go/G, phase.Apoptosis Analysis Cell Line:A-549 cells Concentration:5 μM Incubation Time:24 h Result:Increased the percentage of total apoptotic cells by a factor of 13 from 0.51 to 6.68%.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Monocarboxylate Transporter
  • Recptor
    Monocarboxylate transporter
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2878360-80-4
  • Formula Weight
    389.4
  • Molecular Formula
    C22H19N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(=C(C(OC)=O)C#N)C=1C=2C(N(CC(NC3=CC=C(OC)C=C3)=O)C1)=CC=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sachin Puri, et al. Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1). J Med Chem. 2023 Jan 12;66(1):657-676.?
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