MC1742

CAS No. 1776116-74-5

MC1742( —— )

Catalog No. M34786 CAS No. 1776116-74-5

MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    MC1742
  • Note
    Research use only, not for human use.
  • Brief Description
    MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).
  • Description
    MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC.
  • In Vitro
    MC1742 (compound 1) (0.5 and 2 μM; 24 hours) increases acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3.MC1742 (0.5, 1 and 2 μM; 24, 48 and 72 hours) significantly induces apoptosis of all CSC cultures.MC1742 (0.025-0.5 μM; 14 days) enhances bone nodule formation in a significantdose-dependent manner.Immunofluorescence Cell Line:Sarcoma cancer stem cells Concentration:0.5 and 2 μM Incubation Time:24 hours Result:Increased acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3.Apoptosis Analysis Cell Line:Sarcoma cancer stem cells Concentration:0.5, 1 and 2 μM Incubation Time:24, 48 and 72 hours Result:Significantly induced apoptosis of all CSC cultures.Cell Differentiation Assay Cell Line:Sarcoma cancer stem cells Concentration:0.025, 0.05, 0.1 and 0.5 μM Incubation Time:14 days Result:Successfully enhanced bone nodule formation in a significantdose-dependent manner.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1776116-74-5
  • Formula Weight
    395.47
  • Molecular Formula
    C21H21N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (505.73 mM; Ultrasonic )
  • SMILES
    S(CCCCC(NO)=O)C=1NC(=CC(=O)N1)C2=CC=C(C=C2)C3=CC=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Di Pompo G, et al. Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J Med Chem. 2015;58(9):4073-4079.?
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