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MBCQ
CAS No. 150450-53-6
MBCQ( —— )
Catalog No. M22973 CAS No. 150450-53-6
MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.MBCQ, a selective PDE5 inhibitor, significantly decreased the EC(50) values for GTN-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift occurring in tolerant veins.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 38 | In Stock |
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| 5MG | 61 | In Stock |
|
| 10MG | 110 | In Stock |
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| 25MG | 222 | In Stock |
|
| 50MG | 368 | In Stock |
|
| 100MG | 531 | In Stock |
|
| 500MG | 1143 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMBCQ
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NoteResearch use only, not for human use.
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Brief DescriptionMBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.MBCQ, a selective PDE5 inhibitor, significantly decreased the EC(50) values for GTN-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift occurring in tolerant veins.
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DescriptionMBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.MBCQ, a selective PDE5 inhibitor, significantly decreased the EC(50) values for GTN-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift occurring in tolerant veins.
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In VitroMBCQ (compound 3d) induces relaxation of isolated porcine coronary arteries precontracted with prostaglandin F2α (PGF2α; EC50=190 nM). MBCQ (0.01-10 μM; 10 min) inhibits Carbachol (10 μM)-induced contractions in a concentration-dependent manner in rat ileal smooth muscle.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE5
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Research Area——
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Indication——
Chemical Information
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CAS Number150450-53-6
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Formula Weight313.74
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Molecular FormulaC16H12ClN3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (318.74 mM)
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SMILESClC1=CC2=C(N=CN=C2NCC3=CC=C(OCO4)C4=C3)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Macpherson J D , Gillespie T D , Dunkerley H A , et al. Inhibition of Phosphodiesterase 5 Selectively Reverses Nitrate Tolerance in the Venous Circulation[J]. Journal of Pharmacology & Experimental Therapeutics, 2006, 317(1):188.
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