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MB-07811

CAS No. 852948-13-1

MB-07811 ( VK-2809 )

Catalog No. M26750 CAS No. 852948-13-1

MB-07811 is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity. MB-07811 is an agonist of liver-targeted THR-β.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MB-07811
  • Note
    Research use only, not for human use.
  • Brief Description
    MB-07811 is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity. MB-07811 is an agonist of liver-targeted THR-β.
  • Description
    MB-07811 is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity. MB-07811 is an agonist of liver-targeted THR-β.(In Vitro):MB-07811 has a low affinity for thyroid hormone receptors with a Ki of 14.6 μM for TRβ and a Ki of 12.5 μM for TRα.(In Vivo):In diet-induced obese mice, MB-07811 (0.3-30 mg/kg) decreases cholesterol and triglycerides.
  • Synonyms
    VK-2809
  • Pathway
    Endocrinology/Hormones
  • Target
    THR
  • Recptor
    SST2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    852948-13-1
  • Formula Weight
    515.0
  • Molecular Formula
    C28H32ClO5P
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)c1cc(Cc2c(C)cc(OC[P@@]3(=O)OCC[C@H](O3)c3cccc(Cl)c3)cc2C)ccc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Murray B. Gordon, et al. Identification of a dose range for once daily oral paltusotine in patients with acromegaly that maintains IGF-1 levels when switching from long-acting somatostatin receptor ligand therapy. Endocrine Abstracts (2021) 73 OC15.4.
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