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MAP3K14-IN-173
CAS No. 2113617-02-8
MAP3K14-IN-173( MAP3K14 inhibitor )
Catalog No. M13357 CAS No. 2113617-02-8
A novel potent MAP3K14 kinase inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1683 | Get Quote |
|
| 50MG | 3402 | Get Quote |
|
| 100MG | 4680 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMAP3K14-IN-173
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent MAP3K14 kinase inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).
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DescriptionA novel potent MAP3K14 kinase inhibitor with IC50 of 1.8 nM (NIK autophosphorylation); inhibits p-IKKα levels of L363 (NIK translocated multiple myeloma) cells with IC50 of 1.3 nM; exhibits antiproliferative activity on JJN-3 (NIK translocated) multiple myeloma cells (IC50=29 nM).
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In Vitro——
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In Vivo——
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SynonymsMAP3K14 inhibitor
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK
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Research Area——
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Indication——
Chemical Information
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CAS Number2113617-02-8
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Formula Weight509.614
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Molecular FormulaC29H31N7O2
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Purity>98% (HPLC)
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Solubility——
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SMILESN#CC1=CC(C2=NC(NC3=CC(C#N)=C(CCN4CCOCC4)C=C3C)=NC=C2)=CC5=C1NC[C@@]5(CO)C
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Chemical Name(R)-5-(2-((5-cyano-2-methyl-4-(2-morpholinoethyl)phenyl)amino)pyrimidin-4-yl)-3-(hydroxymethyl)-3-methylindoline-7-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kargbo RB, et al. ACS Med Chem Lett. 2017 Aug 17;8(9):908-910.
2. Patent WO2017125530 A1, compound example 173.
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