Contraceptive Tetrapeptide

Research use only, not for human use.

Kentsin, a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation. Kentsin has opiate properties on gastrointestinal motility.

Kentsin, as a contraceptive polypeptide, has central opiate properties on gastrointestinal motility.

Kentsin (100 μg/mL, 18 h) increases endogenous xenotropic virus expression in K-Balb 19a/h cells transformed with Kirsten sarcoma virus.Kentsin (30 μM) does not inhibit electrically stimulated contractions of the guinea pig ileum (GPI) or mouse vas deferens (MVD).

Kentsin (0-100 μg, i.c.v. or intrathecal administration) produces analgesia in both the hotplate and abdominal stretch tests.Kentsin (20 and 100 ng/kg, i.c.v.) inhibits the antral motility index and disrupts the jejunal migrating motor complex in fasted dogs.Kentsin (4.0 μg/kg, i.c.v. 2 hours after the beginning of a meal) restores the “fasted” (the migrating myoelectric complex of intestinal motility), and can be blocked by previous Naloxone (400 μg/kg, i.c.v.).Animal Model:Fasted dogs Dosage:20 and 100 ng/kg Administration:Intracerebroventricular injection (i.c.v.)Result:Inhibited the antral motility index by 51.2 and 76.1%.Disrupted the jejunal migrating motor complex for 2 and 4 h respectively.

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Others

Other Targets

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56767-30-7

500.6

C21H40N8O6

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years