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Granuliberin R

CAS No. 64704-41-2

Granuliberin R( ——— )

Catalog No. M41894 CAS No. 64704-41-2

Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Granuliberin R
  • Note
    Research use only, not for human use.
  • Brief Description
    Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine.
  • Description
    Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa.
  • In Vitro
    Granuliberin R (10 μg/mL) does not alter the release of catecholamines and adenine nucleotides from cultured adrenal chromaffin cells, while the Mastoparan (10 μg/mL) increases both of them.
  • In Vivo
    Granuliberin R (0.1 mg/mL, 1 μg/mL, and 10 ng/mL; injection; single dose for 60 s) interfere in the proliferation of oral keratinocytes and the activity of connective tissue cells when treatment is conducted into rats mandibular gingiva in the vicinity of the right mental foramen.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    64704-41-2
  • Formula Weight
    1422.71
  • Molecular Formula
    C69H103N19O14
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nakajima T, et al. A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin. Chem Pharm Bull (Tokyo). 1977 Sep;25(9):2464-5.?
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