FMRF - related peptide, Lymnaea heptapeptide

Dimethylamine (DMA) is abundantly present in human urine. Main sources of urinary DMA have been reported to include trimethylamine N-oxide a common food component and asymmetric dimethylarginine (ADMA) an endogenous inhibitor of nitric oxide (NO) synthesis.

Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein.