TPI-1 is a SHP-1 inhibitor.

25-Furandicarboxylic acid is a normal urinary metabolite in humans. 25-Furandicarboxylic acid is also a microbial metabolite a product of the oxidation of hydroxymethylfurfural (HMF) by the enzyme furfural/HMF oxidoreductase which is found in the bacterium Cupriavidus basilensis.

Taccalonolide AJ is a microtubule stabilizer; it has excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its short half-life in vivo.