AKOS B018304 is an arylalkylidene derivative with polar substitution at para-position.

DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit NF-κB activity.DCZ0415 (10, 20 μM; 72 hours) showed a marked reduction in colony formation, indicating that it inhibited cell proliferation.

Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity.