R9( ——— )

Catalog No. M40980 CAS No. 143413-47-2

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Product Name

R9
Note

Research use only, not for human use.
Brief Description

(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
Description

(Arg)9 (Nona-L-arginine;Peptide R9) is a cell-penetrating peptide,and exhibits neuroprotective activity(IC50 of 0.78 μM, in the glutamic acid model).
In Vitro

(Arg)9 (Nona-L-arginine; 5-10 μM) provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC50=6 μM).
In Vivo

(Arg)9 (Nona-L-arginine; 1μM/kg (600 μL); i.v.; once, for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) shows neuroprotective effects and reduces infarct volume.Animal Model:Male Sprague–Dawley rats (270 to 320?g) permanent middle cerebral artery stroke model Dosage:1 μM/kg (600? μL) Administration:Intravenous injection; once, over 5 minutes Result:Reduced significantiy 20% in infarct volume.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

neuroprotection
Research Area

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Indication

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1. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.?

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