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(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)
CAS No. 77128-69-9
(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)( ——— )
Catalog No. M40440 CAS No. 77128-69-9
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P analogue that has approximately the same effects as Substance P on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 74 | In Stock |
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| 10MG | 131 | In Stock |
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| 25MG | Get Quote | In Stock |
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| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)
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NoteResearch use only, not for human use.
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Brief Description[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P analogue that has approximately the same effects as Substance P on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.
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Description[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P analogue that has approximately the same effects as Substance P on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.
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In Vitro———
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In VivoAnimal Model:Male Sprague-Dawley rats (300-350 g).Dosage:2 μg/side Administration:Inject into the ventral tegmental area; single Result:Selectively activated mesolimbic and mesocortical dopamine metabolism.Animal Model:Male Wistar rats (300-350 g).Dosage:0.5, 1.5, 3 μg/side Administration:Inject into the ventral tegmental area; single Result:Significantly increased locomotor activity when at 3 μg/side.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number77128-69-9
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Formula Weight880.06
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Molecular FormulaC43H61N9O9S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL (113.63 mM; )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7. ?
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