Substance P (1-4)
CAS No. 57468-16-3
Substance P (1-4)( ——— )
Catalog No. M40433 CAS No. 57468-16-3
Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSubstance P (1-4)
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NoteResearch use only, not for human use.
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Brief DescriptionSubstance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation.
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DescriptionSubstance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation.
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In VitroSubstance P(1-4) (0.1 nM-1 μM) inhibits endogenous erythroid colony (EEC) formation in PV bone marrow cultures.Substance P(1-4) (0.1 nM-1 μM; CD36+/GpA- cells) decreases of erythroid colony numbers of 47% and inhibits proliferation of PV CD36+/GpA- cells of 30 %.Cell Viability Assay Cell Line:PV CD36+/GpA- cells Concentration:0.1 nM-1 μM Incubation Time:2 days Result:Inhibited proliferation of PV CD36+/GpA- cells of 30 %.Apoptosis Analysis Cell Line:PV CD36+/GpA- cells Concentration:10 nM Incubation Time:2 days Result:Increased the percentage of cell death of 27.3%.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number57468-16-3
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Formula Weight496.6
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Molecular FormulaC22H40N8O5
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Le Gall C, et, al. Inhibitory effect of the substance P and its derivative on erythropoietin-independent growth of erythroid progenitors in polycythemia vera. Leuk Res. 2008 May;32(5):743-54.?
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