(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)( ——— )

Catalog No. M40375 CAS No. 118102-98-0

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Product Name

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
Note

Research use only, not for human use.
Brief Description

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.
Description

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.
In Vitro

(D-Trp12,Tyr34)-pTH (7-34) amide (0.05-10 μM) causes a concentration-dependent inhibition of PTHrP or PTH-stimulated cAMP formation in opossum kidney (OK) cells.(D-Trp12,Tyr34)-pTH (7-34) amide (0.1-10 μM) attenuates inhibition of NapiT promoted by 1 nM of either PTHrP or PTH.
In Vivo

(D-Trp12,Tyr34)-pTH (7-34) amide (1 mg/mL once, 0.1 mg/mL for 6 h; i.v.) has no significant effect on serum calcium levels in hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung.
Synonyms

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Pathway

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Target

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Recptor

Ki: 69 nM (PTH)
Research Area

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Indication

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1. Goldma ME, et, al. A new highly potent parathyroid hormone antagonist: D-Trp12,Tyr34bPTH-(7-34)NH2. Endocrinology. 1988 Nov; 123(5): 2597-9.?

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