Protein Kinase C (530-558)( ——— )

Catalog No. M40351 CAS No. 122613-29-0

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Product Name

Protein Kinase C (530-558)
Note

Research use only, not for human use.
Brief Description

Protein Kinase C (530-558), a peptide fragment of protein kinase C (PKC), is a potent PKC activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption.
Description

Protein Kinase C (530-558), a peptide fragment of protein kinase C (PKC), is a potent PKC activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption.
In Vitro

Protein Kinase C (530-558) (1 nM-1 μM, 24 h) causes a dose-responsive inhibition of bone resorption, which is accompanied by a rapid and distinctive change in osteoclast morphology.Cell Viability Assay Cell Line:Osteoclast cell Concentration:1 nM, 10 nM, 100 nM, 1 μM Incubation Time:24 h Result:Showed a dose-responsive, marked inhibition of bone resorption was observed between 10 nM and 1 μM. At 1 μM, resorption was inhibited by more thaln 87 %.
In Vivo

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Indication

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1. Moonga BS, et al. Effects of peptide fragments of protein kinase C on isolated rat osteoclasts. Exp Physiol. 1998 Nov;83(6):717-25.?

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