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cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)
cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)
CAS No. 100853-58-5
cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)( ——— )
Catalog No. M40331 CAS No. 100853-58-5
PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NamecAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)
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NoteResearch use only, not for human use.
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Brief DescriptionPKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors.
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DescriptionPKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors.
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In VitroPKI(5-22)amide (1 μM; 1 min) fails to block CRF1?receptor (100 nM; 30 min) desensitization in Y-79 cells permeabilized with Streptolysin O .
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number100853-58-5
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Formula Weight1969.2
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Molecular FormulaC84H137N29O26
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dautzenberg FM, et al. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46. ?
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